Objective: To find out the protective effect of Nigella Sativa (NS) on Doxorubicin (DOX) induced histomorphometric changes in male albino rat. Methodology: Forty Albino Rats (221 to 238 g), grouped into four. Group A = Control, Group B= Dox (3 mg/ kg bw/week, intraperitonealy) for 5 weeks, Group C= NS (1000mg/ kg bw, orally) daily and doxorubicin (3 mg/kg bw/week, intraperitonealy) for 5 weeks and Group D= NS (1000mg/kg bw, orally) throughout study. Results: Mean thickness of germinal epithelium (TGE) in group A was 63.289+2.234 µm.  Mean  diameter  (um)  of  seminiferous  tubules  (DST)  in  group  A was 240.349+6.294 µm.   Mean (TGE) of group B was  33.641+2.561 and  mean (DST) of group B was 175.759+5.518. There were highly significant decreases in (p0.001) (p0.0001) (TGE) and (DST) respectively of group B when compared with group A. Mean (TGE) of group C was 59.067+1.890 and mean (DST) of group C was 228.083+4.576. There were insignificant decreases in (p0.1663) (p0.252) (TGE) and (DST) respectively of group C when compared with group A. The data also showed highly significant increases in (p0.007) (p 0.001) (TGE) and (DST) respectively when compared with group B. Mean (TGE) of group D was 73.411+1.549, mean (DST) of group D was 266.951+6.883. There were highly significant increases in (p 0.002) and (p0.048) (TGE) and (DST) respectively of group D when compared with group A. There were highly significant increases in (p 0.0001) and (p0.0001) (TGE) and (DST) respectively of group D when compared with the group B. Conclusion: NS increases DST and TGE of the Dox toxicated and normal rat.